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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T79376 | SARS-CoV-2 3CLpro-IN-19 | SARS-CoV | |
SARS-CoV-2 3CLpro-IN-19 (Compound C5a), a non-covalent, non-peptide inhibitor of the SARS-CoV-2 3CLpro enzyme, exhibits potent in vitro activity with an IC50 of 0.7 μM. It demonstrates broad-spectrum efficacy against inf... | |||
T9458 | PF-00835231 | SARS-CoV | |
PF-00835231 is a CoV-2 cysteine 3C-like protease (3CLpro) inhibitor, with IC50s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CLpro, respectively.PF-00835231 is the active compound of the first anti-3CLpro regimen i... | |||
T60095 | CCF0058981 | SARS-CoV | |
CCF0058981 (CCF981) is a 3-chlorophenyl analogue, serving as a noncovalent inhibitor of SARS-CoV-2 3CL pro (SC2), demonstrating potent activity with an IC50 of 68 nM. It also exhibits inhibitory effects against SARS-CoV-... | |||
T72370 | SARS-CoV-2 3CLpro-IN-6 | ||
SARS-CoV-2 3CLpro-IN-6 is a reversible covalent inhibitor targeting the SARS-CoV-2 3CL protease, demonstrating potent inhibitory activity with an IC50 of 4.9 μM. It is utilized in the research of coronavirus disease 2019... | |||
T80657 | SARS-CoV-2 3CLpro-IN-15 | Virus Protease | |
SARS-CoV-2 3CLpro-IN-15 (compound a), a beta-nitrostyrene derivative, acts as an inhibitor of the SARS-CoV-2 3CL protease (3CLpro), effectively inhibiting viral replication and transcription. It is instrumental in the id... | |||
T9686 | YH-53 | ||
YH-53 is a potent 3CLpro inhibitor, exhibiting K i values of 6.3 nM and 34.7 nM against SARS-CoV-1 3CLpro and SARS-CoV-2 3CLpro, respectively. This peptidomimetic compound, characterized by its unique benzothiazolyl keto... | |||
T72364 | SARS-CoV-2 3CLpro-IN-5 | SARS-CoV | |
SARS-CoV-2 3CLpro-IN-5 is a covalent inhibitor targeting the 3C-like protease (3CLpro), exhibiting potent inhibitory activity with an IC50 of 3.8 nM and demonstrating 9.0% oral bioavailability (BA). It is utilized in the... | |||
T63760 | 3CPLro-IN-2 | ||
3CPLro-IN-2 is a potent, orally active inhibitor of SARS-CoV-2 3CLpro (IC50: 1.55 μM, Ki: 6.09 μM). 3-Chymotrypsin-like cysteine protease (3CLpro) is an essential protein for viral replication and is a potential drug tar... | |||
T62479 | 3CPLro-IN-1 | ||
3CPLro-IN-1 (compound A17) is a potent, orally active inhibitor of SARS-CoV-2 3CLpro (IC50: 5.65 μM). 3-Chymotrypsin-like cysteine protease (3CLpro), a protein essential for viral replication, is an attractive drug targe... |